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. 2004 Apr;48(4):1347-9.
doi: 10.1128/AAC.48.4.1347-1349.2004.

Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides

O Y Misyurina  1 , E V Chipitsyna, Y P Finashutina, V N Lazarev, T A Akopian, A M Savicheva, V M Govorun
Affiliations

Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides

O Y Misyurina et al. Antimicrob Agents Chemother. 2004 Apr.

Abstract

For six clinical isolates of Chlamydia trachomatis, in vitro susceptibility to erythromycin, azithromycin, and josamycin has been determined. Four isolates were resistant to all the antibiotics and had the mutations A2058C and T2611C (Escherichia coli numbering) in the 23S rRNA gene. All the isolates had mixed populations of bacteria that did and did not carry 23S rRNA gene mutations.

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Figures

FIG. 1.
FIG. 1.
The secondary structure of the central portion of domain V (the peptidyl transferase loop) of the 23S rRNA gene of a C. trachomatis clinical isolate resistant to azithromycin (as determined on the basis of the model by Egebjerg et al.) (2). The arrows show mutations A2058C to T2611C (E. coli numbering).
See this image and copyright information in PMC

References

    1. Berisio, R., J. Harms, F. Schluenzen, R. Zarivach, P. Fucini, and A. Yonath. 2003. Structural insight into the antibiotic action of telithromycin against resistant mutants. J. Bacteriol. 185:4276-4279. - PMC - PubMed
    1. Canu, A., B. Malbruny, M. Coquemont, T. A. Davies, P. C. Appelbaum, and R. Leclercq. 2002. Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 46:125-131. - PMC - PubMed
    1. Egebjerg, J., N. Larsen, and R. A. Garrett. 1990. Structural map of 23S rRNA, p. 168-179. In W. E. Hill, A. Dalberg, R. A. Garrett, P. B. Moore, D. Schlessinger, and J. R. Warner (ed.), The ribosome: structure, function, and evolution. American Society for Microbiology, Washington, D.C.
    1. Engel, J. N., and D. Ganem. 1987. Chlamydial rRNA operons: gene organization and identification of putative tandem promoters. J. Bacteriol. 169:5678-5685. - PMC - PubMed
    1. Ettayebi, M., S. M. Prasad, and E. A. Morgan. 1985. Chloramphenicol-erythromycin resistance mutations in a 23S rRNA gene of Escherichia coli. J. Bacteriol. 162:551-557. - PMC - PubMed

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