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Case Reports
. 2004 Apr;48(4):1382-3.
doi: 10.1128/AAC.48.4.1382-1383.2004.

Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis

Steve Hernandez  1 , José L López-Ribot, Laura K Najvar, Dora I McCarthy, Rosie Bocanegra, John R Graybill
Affiliations
Case Reports

Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis

Steve Hernandez et al. Antimicrob Agents Chemother. 2004 Apr.

Abstract

A patient with azole-refractory thrush-esophagitis responded initially to caspofungin, but the treatment eventually failed. In a murine model, caspofungin was effective against two early isolates for which the MICs of caspofungin were low, but it was less effective against a late isolate for which the MIC of caspofungin was greater. We concluded that there is a correlation between in vivo failure and rising in vitro caspofungin MICs.

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References

    1. Arathoon, E. G., E. Gotuzzo, L. M. Noriega, R. S. Berman, M. J. DiNubile, and C. A. Sable. 2002. Randomized, double-blind, multicenter study of caspofungin versus amphotericin B for treatment of oropharyngeal and esophageal candidiasis. Antimicrob. Agents Chemother. 46:451-457. - PMC - PubMed
    1. Douglas, C. M., J. A. D'ippolito, G. J. Shei, M. Meinz, J. Onishi, J. A. Marrinan, W. Li, G. K. Abruzzo, A. Flattery, K. Bartizal, A. Mitchell, and M. B. Kurtz. 1997. Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-β-d-glucan synthase inhibitors. Antimicrob. Agents Chemother. 41:2471-2479. - PMC - PubMed
    1. Ernst, E. J., M. E. Klepser, and M. Pfaller. 2000. Postantifungal effects of echinocandin, azole, and polyene antifungal agents against Candida albicans and Cryptococcus neoformans. Antimicrob. Agents Chemother. 44:1108-1111. - PMC - PubMed
    1. Graybill, J. R. 1995. Antifungal drugs and resistance. Adv. Exp. Med. Biol. 390:217-234. - PubMed
    1. Hector, R. F. 1993. Compounds active against cell walls of medically important fungi. Clin. Microbiol. Rev. 6:1-21. - PMC - PubMed

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