[The role of tumor markers in the diagnosis and follow-up of liver tumors]

Abstract

A comprehensive survey on the tumour markers in the diagnosis and follow up of hepatocellular carcinoma (HCC) is given by the author. In addition to AFP, the "classical" HCC marker, other substances with potential clinical laboratory benefits are also described. The various marker combinations and the role of certain molecular "isoforms" are evaluated in terms of differential diagnosis of benignity/malignity. Since the long survival of patients with HCC depends primarily on successful liver resection the attention is directed to the significance of AFP mRNA, the predictive marker of recurring HCC.