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. 2004 Mar;54(1):49-56.

Anticonvulsant activity of Schiff bases of isatin derivatives

Manjusha Verma  1 , Surendra Nath Pandeya, Krishna Nand Singh, James P Stables
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  • PMID: 15050044

Anticonvulsant activity of Schiff bases of isatin derivatives

Manjusha Verma et al. Acta Pharm. 2004 Mar.

Abstract

Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin (2) exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs phenytoin, carbamazepine and valproic acid. Thus, compound 2 may be chosen as a prototype for development of new anticonvulsants.

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