Correlation of TIMI risk score with angiographic severity and extent of coronary artery disease in patients with non-ST-elevation acute coronary syndromes

Abstract

The Thrombolysis In Myocardial Infarction (TIMI) risk score predicts adverse clinical outcomes in patients with non-ST-elevation acute coronary syndromes (NSTEACS). Whether this score correlates with the coronary anatomy is unknown. We sought to determine whether the TIMI risk score correlates with the angiographic extent and severity of coronary artery disease (CAD) in patients with NSTEACS undergoing cardiac catheterization. We conducted a retrospective review of 688 consecutive medical records of patients who underwent coronary angiography secondary to NSTEACS. Patients were classified into 3 categories according to TIMI risk score: TIMI scores 0 to 2 (n = 284), 3 to 4 (n = 301), and 5 to 7 (n = 103). One-vessel disease was found in patients with TIMI score 3 to 4 as often as in patients with TIMI score 0 to 2 (odds ratio [OR] 1.08, 95% confidence interval [CI] 0.74 to 1.56; p = 0.66). However, 1-vessel disease was found more often in patients with TIMI score 3 to 4 than in patients with TIMI score 5 to 7 (OR 2.16, 95% CI 1.18 to 3.95; p = 0.01), and in patients with TIMI score 0 to 2 than in those with TIMI score 5 to 7 (OR 1.99, 95% CI 1.08 to 3.66; p = 0.02). Two-vessel disease was more likely found in patients with TIMI score 3 to 4 than in those with TIMI scores 0 to 2 (OR 3.96, 95% CI 2.41 to 6.53; p <0.001) and 5 to 7 (OR 2.05, 95% CI 1.12 to 3.75; p = 0.004). Three-vessel or left main disease was more likely found in patients with TIMI score 3 to 4 than in patients with TIMI score 0 to 2 (OR 3.19, 95% CI 2.00 to 5.10; p <0.001), and in patients with TIMI score 5 to 7 than in patients with TIMI score 3 to 4 (OR 6.34, 95% CI 3.88 to 10.36; p <0.001). In patients with NSTEACS undergoing cardiac catheterization, the TIMI risk score correlated with the extent and severity of CAD.