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Comment
. 2004 Apr 6;101(14):4723-4.
doi: 10.1073/pnas.0401376101. Epub 2004 Mar 29.

Stromal fibroblasts influence human mammary epithelial cell morphogenesis

Daniel Medina  1
Affiliations
Comment

Stromal fibroblasts influence human mammary epithelial cell morphogenesis

Daniel Medina. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
An idealized view of epithelial–stromal interactions based on the results of Kuperwasser et al. (6). “Normal” fibroblasts (yellow) support growth and normal morphogenesis of human mammary epithelial cells as a xenograft. Ducts and terminal ductal lobular units (TDLU) are a normal morphogenic signature. Fibroblasts (orange) engineered to express the hepatocyte growth factor (HGF) at high levels promote the outgrowth of premalignant mammary epithelium, ductal carcinoma in situ (DCIS). In this model, fibroblasts can dictate the morphogenic pathway of mammary epithelial cells (drawing courtesy of Anne Shepard, Baylor College of Medicine).
See this image and copyright information in PMC

Comment on

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