Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Mar;74(3):399-402.
doi: 10.1086/382659.

2003 Curt Stern Award address. On low expectation exceeded; or, the genomic salvation of the Y chromosome

David C Page  1
Affiliations

2003 Curt Stern Award address. On low expectation exceeded; or, the genomic salvation of the Y chromosome

David C Page. Am J Hum Genet. 2004 Mar.
No abstract available

PubMed Disclaimer

Figures

None
David C. Page (courtesy Sam Ogden)
Figure 1
Figure 1
The Y chromosome’s AZFc region, a deletion-prone hall of mirrors (adapted from Kuroda-Kawaguchi et al. [2001] and Repping et al. [2003]). A, Dot plot in which a 4.5-Mb portion of the human Y chromosome, including AZFc, is compared with itself. The base of the plot depicts the organization of amplified segments, or amplicons, including those labeled b1–b4 (blue), g1–g3 (green), and r1–r4 (red). Within the plot, each dot represents a perfect match of 500 bp. Direct repeats appear as horizontal lines, inverted repeats as vertical lines, and palindromes as vertical lines that nearly intersect the baseline. Palindromes P1, P2, and P3 are indicated, as are the direct repeats responsible for the b2/b4 and gr/gr deletions. Within the plot, tinted squares reflect pairs of amplicons with >99.9% identical sequences. Gray diagonal lines mark amplicon boundaries within the plot. Orientation with respect to centromere (cen) and long-arm telomere (qter) is shown. B, The blue arch highlights the regions demarcating the b2/b4 (AZFc) deletion. C, The green arch highlights the regions demarcating the gr/gr deletion.
Figure 2
Figure 2
Expression of Stra8 in XX and XY mouse embryonic gonads at 12.5–16.5 d following fertilization (from Menke et al. [2003], where details of this whole-mount in situ hybridization analysis can be found). Gonads are oriented with anterior poles at the top.
See this image and copyright information in PMC

References

    1. Ford CE, Miller OJ, Polani PE, de Almeida JC, Briggs JH (1959) A sex-chromosome anomaly in a case of gonadal dysgenesis (Turner’s syndrome). Lancet 1:711–71310.1016/S0140-6736(59)91893-8 - DOI - PubMed
    1. Jacobs PA, Strong JA (1959) A case of human intersexuality having a possible XXY sex determining mechanism. Nature 183:302–303 - PubMed
    1. Koopman P, Gubbay J, Vivian N, Goodfellow P, Lovell-Badge R (1991) Male development of chromosomally female mice transgenic for Sry. Nature 351:117–12110.1038/351117a0 - DOI - PubMed
    1. Kuroda-Kawaguchi T, Skaletsky H, Brown LG, Minx PJ, Cordum HS, Waterston RH, Wilson RK, Silber S, Oates R, Rozen S, Page DC (2001) The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men. Nat Genet 29:279–28610.1038/ng757 - DOI - PubMed
    1. Lahn BT, Page DC (1999) Four evolutionary strata on the human X chromosome. Science 286:964–96710.1126/science.286.5441.964 - DOI - PubMed

Publication types

LinkOut - more resources