Miltefosine: an oral drug for visceral leishmaniasis
- PMID: 15053378
- DOI: 10.1007/BF02723096
Miltefosine: an oral drug for visceral leishmaniasis
Abstract
Miltefosine, a phosphocholine analogue originally developed as antimalignant drug, has been found to be highly active against leishmania in vitro and animal model. Based on these experiences this drug was tried against human visceral leishmaniasis and found to be highly effective and achieved 97% and 94% cure in phase 2 and phase 3 trial in children.
Similar articles
-
Oral miltefosine treatment in children with visceral leishmaniasis: a brief review.Braz J Infect Dis. 2008 Feb;12(1):2-4. doi: 10.1590/s1413-86702008000100002. Braz J Infect Dis. 2008. PMID: 18553005 Review.
-
[Treatment of visceral leishmaniasis: efficacy and limits of miltefosine].Sante. 2001 Oct-Dec;11(4):257-8. Sante. 2001. PMID: 11861203 Review. French. No abstract available.
-
Miltefosine: great expectations against visceral leishmaniasis.J Postgrad Med. 2003 Jan-Mar;49(1):101-3. doi: 10.4103/0022-3859.911. J Postgrad Med. 2003. PMID: 12865588 Review. No abstract available.
-
Miltefosine--discovery of the antileishmanial activity of phospholipid derivatives.Trans R Soc Trop Med Hyg. 2006 Dec;100 Suppl 1:S4-8. doi: 10.1016/j.trstmh.2006.03.009. Epub 2006 Aug 14. Trans R Soc Trop Med Hyg. 2006. PMID: 16904717 Review.
-
New insights with miltefosine unresponsiveness in Brazilian Leishmania infantum isolates.EBioMedicine. 2018 Nov;37:13-14. doi: 10.1016/j.ebiom.2018.10.016. Epub 2018 Oct 9. EBioMedicine. 2018. PMID: 30314891 Free PMC article. No abstract available.
Cited by
-
Pharmacokinetics of oral sitamaquine taken with or without food and safety and efficacy for treatment of visceral leishmaniais: a randomized study in Bihar, India.Am J Trop Med Hyg. 2011 Jun;84(6):892-900. doi: 10.4269/ajtmh.2011.10-0409. Am J Trop Med Hyg. 2011. PMID: 21633025 Free PMC article. Clinical Trial.
-
Miltefosine: First Oral Drug for Treatment of Visceral Leishmaniasis.Med J Armed Forces India. 2006 Jan;62(1):66-7. doi: 10.1016/S0377-1237(06)80162-0. Epub 2011 Jul 21. Med J Armed Forces India. 2006. PMID: 27407849 Free PMC article. No abstract available.
-
Persistence and Changing Distribution of Leishmaniases in Kenya Require a Paradigm Shift.J Parasitol Res. 2021 Oct 18;2021:9989581. doi: 10.1155/2021/9989581. eCollection 2021. J Parasitol Res. 2021. PMID: 34707907 Free PMC article. Review.
-
Review of Leishmaniasis Treatment: Can We See the Forest through the Trees?Pharmacy (Basel). 2024 Feb 8;12(1):30. doi: 10.3390/pharmacy12010030. Pharmacy (Basel). 2024. PMID: 38392937 Free PMC article. Review.