RelA life and death decisions
- PMID: 15053867
- DOI: 10.1016/s1097-2765(04)00158-3
RelA life and death decisions
Abstract
RelA is generally regarded as an activator of prosurvival gene transcription. However, in this issue of Molecular Cell, demonstrate that anticancer drugs turn RelA into an accomplice of apoptosis by instructing it to dominantly repress survival gene transcription.
Comment on
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Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.Mol Cell. 2004 Mar 26;13(6):853-65. doi: 10.1016/s1097-2765(04)00131-5. Mol Cell. 2004. PMID: 15053878
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