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Review
. 2004;5(4):105.
doi: 10.1186/gb-2004-5-4-105. Epub 2004 Mar 25.

The mammalian transcriptome and the function of non-coding DNA sequences

Svetlana A Shabalina  1 , Nikolay A Spiridonov
Affiliations
Review

The mammalian transcriptome and the function of non-coding DNA sequences

Svetlana A Shabalina et al. Genome Biol. 2004.

Abstract

For decades, researchers have focused most of their attention on protein-coding genes and proteins. With the completion of the human and mouse genomes and the accumulation of data on the mammalian transcriptome, the focus now shifts to non-coding DNA sequences, RNA-coding genes and their transcripts. Many non-coding transcribed sequences are proving to have important regulatory roles, but the functions of the majority remain mysterious.

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Figures

Figure 1
Figure 1
Ratios of the protein-coding, non-coding, and untranscribed sequences in bacterial, yeast, nematode and mammalian genomes. Estimations of the transcribed and protein-coding parts of genomes are based on the sequence length of annotated genes [3,12,13,73]. Estimation of the transcribed portion of the human genome is based on the sequence length occupied by the annotated genes on chromosomes 6, 7, 14, 20, and 22 [5].
See this image and copyright information in PMC

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