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. 2004 May;74(5):1057-63.
doi: 10.1086/420774. Epub 2004 Apr 2.

Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22

Linda M Brzustowicz  1 , Jaime Simone, Paria Mohseni, Jared E Hayter, Kathleen A Hodgkinson, Eva W C Chow, Anne S Bassett
Affiliations

Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22

Linda M Brzustowicz et al. Am J Hum Genet. 2004 May.

Abstract

Previously, we have reported linkage of markers from chromosome 1q22 to schizophrenia, a finding supported by several independent studies. We have now examined the region of strongest linkage for evidence of linkage disequilibrium (LD) in a sample of 24 Canadian familial-schizophrenia pedigrees. Analysis of 14 microsatellites and 15 single-nucleotide polymorphisms (SNPs) from the 5.4-Mb region between D1S1653 and D1S1677 produced significant evidence (nominal P<.05) of LD between schizophrenia and 2 microsatellites and 6 SNPs. All of the markers exhibiting significant LD to schizophrenia fall within the genomic extent of the gene for carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON), making it a prime positional candidate for the schizophrenia-susceptibility locus on 1q22, although initial mutation analysis of this gene has not identified any schizophrenia-associated changes within exons. Consistent with several recently identified candidate genes for schizophrenia, CAPON is involved in signal transduction in the NMDA receptor system, highlighting the potential importance of this pathway in the etiology of schizophrenia.

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Figures

Figure  1
Figure  1
Map of genomic structure of CAPON with genetic markers indicated. Asterisks (*) indicate SNPs that reach studywide empirical significance for LD at the P<.05 level.
Figure  2
Figure  2
LD (D′) between pairs of SNP markers. Pairs with significant evidence (P<.05) of LD are shaded.
See this image and copyright information in PMC

References

Electronic-Database Information

    1. Center for Inherited Disease Research (CIDR), http://www.cidr.jhmi.edu/
    1. National Center for Biotechnology Information, dbSNP, http://www.ncbi.nlm.nih.gov/SNP/
    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?db=OMIM
    1. Pyrosequencing Technical Support, http://techsupport.pyrosequencing.com
    1. UCSC Genome Browser, http://genome.cse.ucsc.edu/

References

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