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Review
. 2004 Apr 2;117(1):9-15.
doi: 10.1016/s0092-8674(04)00297-1.

Early decision; meiotic crossover interference prior to stable strand exchange and synapsis

Douglas K Bishop  1 , Denise Zickler
Affiliations
Free article
Review

Early decision; meiotic crossover interference prior to stable strand exchange and synapsis

Douglas K Bishop et al. Cell. .
Free article

Abstract

During meiosis, DNA double-strand breaks ultimately yield two types of recombinants: crossovers (CO) and noncrossovers (NCO). Recent studies in budding yeast show the CO/NCO designation occurs before stable strand exchange and thus well before Holliday junction resolution. Chromosome synapsis occurs after CO/NCO designation and is not required for the regulated distribution of COs along chromosomes manifested as CO interference.

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