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Case Reports
. 2004 Apr;144(4):524-6.
doi: 10.1016/j.jpeds.2003.11.025.

Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody responses

Noorbibi Day  1 , Nutthapong Tangsinmankong, Hans Ochs, Rajivi Rucker, Capucine Picard, Jean-Laurent Casanova, Soichi Haraguchi, Robert Good
Affiliations
Case Reports

Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody responses

Noorbibi Day et al. J Pediatr. 2004 Apr.

Abstract

We previously described a girl with recurrent episodes of pneumococcal pneumonia with septicemia and other infections,(1) found to have interleukin-1 receptor-associated kinase 4 deficiency (IRAK-4) deficiency.(2) In this report, we show that our patient is unable to sustain antibody responses either to polysaccharide or protein antigens or to a neoantigen-bacteriophage.

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