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Review
. 2004 Jun;30(6):1235-9.
doi: 10.1007/s00134-004-2272-y. Epub 2004 Apr 7.

Thrombotic microangiopathy: an atypical cause of acute renal failure in patients with acute pancreatitis

Alexandre Boyer  1 , Karim Chadda, Amar Salah, Guy Bonmarchand
Affiliations
Review

Thrombotic microangiopathy: an atypical cause of acute renal failure in patients with acute pancreatitis

Alexandre Boyer et al. Intensive Care Med. 2004 Jun.

Abstract

Objective: To report on the development and treatment of thrombotic microangiopathy, an atypical cause of acute renal failure in patients with acute pancreatitis.

Design: Case reports.

Setting: A 21-bed medical intensive care unit at an university hospital.

Patients: Two men with acute pancreatitis presented with acute renal failure, neurological manifestations, haemolytic anaemia and thrombocytopenia. Both patients required intensive care.

Measurements: Fragmented red cell count; levels of haptoglobin, amylase and lipase; serological testing for Escherichia Coli O157; computed tomography of the abdomen.

Main results: The patients' courses were rapidly favourable after daily plasma exchange. A review of the existing medical literature was also undertaken.

Conclusion: As thrombotic microangiopathy may be life-threatening without administration of fresh frozen plasma or plasma exchange, physicians should consider this disease as a possible cause of acute renal failure in patients with acute pancreatitis.

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References

    1. Ann Hematol. 1992 Nov;65(5):236-7 - PubMed
    1. Gastroenterol Clin Biol. 1990;14(12):1030-2 - PubMed
    1. Pancreas. 2002 Jul;25(1):107-9 - PubMed
    1. Am J Gastroenterol. 1989 Jun;84(6):667-9 - PubMed
    1. Indian Pediatr. 1987 Mar;24(3):249-53 - PubMed

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