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. 2004 Apr 14;126(14):4494-5.
doi: 10.1021/ja049873+.

Asymmetric catalysis using self-assembled chiral bidentate P,P-ligands

James M Takacs  1 , D Sahadeva Reddy, Shin A Moteki, Di Wu, Hector Palencia
Affiliations

Asymmetric catalysis using self-assembled chiral bidentate P,P-ligands

James M Takacs et al. J Am Chem Soc. .

Abstract

A strategy is described for modular catalyst development based upon metal-directed self-assembly of bifunctional subunits around a structural metal to form a heteroleptic complex in which a second set of ligating groups are now suitably disposed to bind a second metal to form a catalytic site. A library of chiral diphosphites was prepared via metal-directed self-assembly and used in a simple asymmetric allylic amination, giving enantiomeric excesses as high as 97%.

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