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Case Reports
. 2004 Apr;42(4):1590-5.
doi: 10.1128/JCM.42.4.1590-1595.2004.

Endocarditis with ruptured cerebral aneurysm caused by Cardiobacterium valvarum sp. nov

Xiang Y Han  1 , Michelle C Meltzer, Joan T Woods, Victor Fainstein
Affiliations
Case Reports

Endocarditis with ruptured cerebral aneurysm caused by Cardiobacterium valvarum sp. nov

Xiang Y Han et al. J Clin Microbiol. 2004 Apr.

Abstract

A fastidious gram-negative bacterium was isolated from the blood of a 37-year-old man who had insidious endocarditis with a sudden rupture of a cerebral aneurysm. Characterization of the organism through phylogenetic and phenotypic analyses revealed a novel species of Cardiobacterium, for which the name Cardiobacterium valvarum sp. nov. is proposed. C. valvarum will supplement the current sole species Cardiobacterium hominis, a known cause of endocarditis. Surgeries and antibiotic treatment cured the patient's infection and associated complications. During cardiac surgery, a congenital bicuspid aortic valve was found to be the predisposing factor for his endocarditis.

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Figures

FIG. 1.
FIG. 1.
(A) Phylogenetic tree of the family Cardiobacteriaceae, with P. aeruginosa as the out-group organism; (B) representative significant mismatches among the Cardiobacterium spp., with listed positions referring to those for C. hominis.
FIG. 2.
FIG. 2.
Gram stain morphology (magnification, ×1000). MDA3079 was grown on blood agar (organism sizes, 1 by 2 to 4 μm) (A) and chocolate agar (organism sizes, 1 by 1.5 to 3 μm) (B). C. hominis was grown on blood agar (organism sizes, 1 by 1.5 to 3 μm) (C) and chocolate agar (organism sizes, 0.7 by 2 to 4 μm) (D).
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