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. 1996 Mar;5(2):95-100.
doi: 10.1002/(SICI)1099-1557(199603)5:2<95::AID-PDS228>3.0.CO;2-4.

Dealing with multiplicities in pharmacoepidemiologic studies

W F Rosenberger  1
Affiliations

Dealing with multiplicities in pharmacoepidemiologic studies

W F Rosenberger. Pharmacoepidemiol Drug Saf. 1996 Mar.

Abstract

The problem of multiplicities arises in almost all aspects of scientific studies. When multiple hypotheses are tested in a study, one must adjust the significance level of individual tests to maintain an overall probability error rate. The reasons for this are explored in a non-technical way. Techniques for dealing with multiplicities are described and motivated and guidelines are given, with implications for both study design and publication.

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