[Substantiation and application of the bone marrow autotransplantation for the treatment of chronic critical ischemia of the lower extremity]

Abstract

Myelography of spongiform substance of the injured os tibia was conducted in 134 patients with chronic arterial insufficiency in III-IV stages. Absence of immature forms of erythrocytes, thrombocytes, increase by 35.2% of quantity of immature forms of granulocytic row, and of lymphocytes by 25.5% was noted. Revision of the main vessels of femoro-popliteo--crural region was done, tibial osteotrepanation and autotransplantation of 7-8 ml of the bone marrow cells suspension into the medial malleolus was performed in the case of impossible reconstructive operation performance. Positive changes of clinical indexes and metabolic activity were observed after the bone marrow autotransplantation operation in soft tissues--by 50% and in the costal one--by 100%. Positive effect of the bone marrow autotransplantation operation was caused by prolonged life capacity of the cells transplanted, which enhances peripheral hemopoiesis and stimulates the bone marrow blood flow. In the III-IIIA stages of ischemia and the perfusion deficiency less than 40% such an intervention proved to be effective in 64% of the patients.