doi: 10.1111/j.2042-7158.1977.tb11272.x.
Synthesis and pharmacological properties of a series of antidopaminergic piperidyl benzamides
- PMID: 15078
- DOI: 10.1111/j.2042-7158.1977.tb11272.x
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Synthesis and pharmacological properties of a series of antidopaminergic piperidyl benzamides
J Pharm Pharmacol.
1977 Mar.
Abstract
The synthesis and pharmacological screening for anti-apomorphine, stomach emptying and local anaesthetic activities of some new piperidylbenzamides is described. One of these, N-(1'-benzyl-4'-piperidyl)-2-methoxy-4-amino-5-chlorobenzamide (clebopride) is more potent than metoclopramide in tests related to blockade of cerebral dopamine receptors.
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