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. 1977 Mar;29(3):147-52.
doi: 10.1111/j.2042-7158.1977.tb11272.x.

Synthesis and pharmacological properties of a series of antidopaminergic piperidyl benzamides

J Prieto, J Moragues, R G Spickett, A Vega, M Colombo, W Salazar, D J Roberts

Synthesis and pharmacological properties of a series of antidopaminergic piperidyl benzamides

J Prieto et al. J Pharm Pharmacol. 1977 Mar.

Abstract

The synthesis and pharmacological screening for anti-apomorphine, stomach emptying and local anaesthetic activities of some new piperidylbenzamides is described. One of these, N-(1'-benzyl-4'-piperidyl)-2-methoxy-4-amino-5-chlorobenzamide (clebopride) is more potent than metoclopramide in tests related to blockade of cerebral dopamine receptors.

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