doi: 10.1016/j.bmcl.2004.02.069.
Synthesis and biochemical properties of E-ring modified luotonin A derivatives
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- PMID: 15080977
- DOI: 10.1016/j.bmcl.2004.02.069
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Synthesis and biochemical properties of E-ring modified luotonin A derivatives
Bioorg Med Chem Lett.
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Abstract
Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.
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