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. 2004 May 3;14(9):2051-4.
doi: 10.1016/j.bmcl.2004.02.069.

Synthesis and biochemical properties of E-ring modified luotonin A derivatives

Ali Cagir  1 , Shannon H Jones, Brian M Eisenhauer, Rong Gao, Sidney M Hecht
Affiliations

Synthesis and biochemical properties of E-ring modified luotonin A derivatives

Ali Cagir et al. Bioorg Med Chem Lett. .

Abstract

Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.

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