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Review
. 2004 May;129(2):133-60.
doi: 10.1016/j.chemphyslip.2004.02.002.

Membrane lipids and cell death: an overview

Affiliations
Review

Membrane lipids and cell death: an overview

Ileana M Cristea et al. Chem Phys Lipids. 2004 May.

Abstract

In this article we overview major aspects of membrane lipids in the complex area of cell death, comprising apoptosis and various forms of programmed cell death. We have focused here on glycerophospholipids, the major components of cellular membranes. In particular, we present a detailed appraisal of mitochondrial lipids that attract increasing interest in the field of cell death, while the knowledge of their re-modelling and traffic remains limited. It is hoped that this review will stimulate further studies by lipid experts to fully elucidate various aspects of membrane lipid homeostasis that are discussed here. These studies will undoubtedly reveal new and important connections with the established players of cell death and their action in promoting or blocking membrane alteration of mitochondria and other organelles. We conclude that the new dynamic era of cell death research will pave the way for a better understanding of the 'chemistry of apoptosis'.

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