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Comparative Study
. 2004 May;239(5):688-95; discussion 695-7.
doi: 10.1097/01.sla.0000124296.46712.67.

Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant

Robert J Stratta  1 , Michael S Rohr, Aimee K Sundberg, Greg Armstrong, Gloria Hairston, Erica Hartmann, Alan C Farney, Julie Roskopf, Samy S Iskandar, Patricia L Adams
Affiliations
Comparative Study

Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant

Robert J Stratta et al. Ann Surg. 2004 May.

Abstract

Objective: To compare outcomes in recipients of expanded criteria donor (ECD) versus standard criteria donor (SCD) kidneys at a single center using a standardized approach with similar immunosuppression.

Summary background data: Expanded criteria deceased organ donors (ECD) are a source of kidneys that permit more patients to benefit from transplantation. ECD is defined as all deceased donors older than 60 years and donors older than 50 years with 2 of the following: hypertension, stroke as the cause of death, or pre-retrieval serum creatinine (SCr) greater than 1.5 mg/dl.

Methods: We retrospectively studied 90 recipients of adult deceased donor kidneys transplanted from October 1, 2001 to February 17, 2003, including 37 (41%) from ECDs and 53 (59%) from SCDs. ECD kidneys were used by matching estimated renal functional mass to recipient need, including the use of dual kidney transplants (n = 7). ECD kidney recipients were further selected on the basis of older age, HLA-matching, low allosensitization, and low body mass index. All patients received a similar immunosuppressive regimen. Minimum follow up was 9 months.

Results: There were significant differences in donor and recipient characteristics between ECD and SCD transplants. Patient (99%) and kidney graft survival (88%) rates and morbidity were similar between the 2 groups, with a mean follow-up of 16 months. Initial graft function and the mean 1-week and 1-, 3-, 6-, 12-, and 18-month SCr levels were similar among groups.

Conclusions: The use of ECD kidneys at our center effectively doubled our transplant volume within 1 year. A systematic approach to ECD kidneys based on nephron mass matching and nephron sparing measures may provide optimal utilization with short-term outcomes and renal function comparable to SCD kidneys.

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Figures

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FIGURE 1. Calculated creatinine clearance, using ideal body weight, in ECDs versus SCDs.
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FIGURE 2. Mean serum creatinine levels at selected time points in ECD versus SCD kidney recipients.
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FIGURE 3. Volume of kidney transplant activity at our center since 1991.
See this image and copyright information in PMC

References

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