Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia
- PMID: 1508406
- DOI: 10.1016/0304-3940(92)90322-x
Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia
Abstract
We studied concentrations of free and total serotonin (5-hydroxytryptamine, 5-HT) and its related substances in the cerebrospinal fluid from patients with Alzheimer type dementia (ATD) compared with controls. In ATD patients, concentrations of total 5-HT, tryptophan, 5-hydroxytryptophan (5-HTP), melatonin, kynurenine, and 3-hydroxykynurenine decreased significantly. The rate of concentration of tryptophan metabolites to that of tryptophan was significantly reduced for total 5-HT and 3-hydroxykynurenine only. The 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio was significantly larger in ATD patients than in controls. The greater reduction in the 3-hydroxykynurenine concentration (81% vs. controls) than in the total 5-HT concentration (51% vs. controls) suggests that the metabolism of tryptophan to 5-HT and 3-hydroxykynurenine is in favor of 5-HT.
Similar articles
-
Indoleamine concentrations in cerebrospinal fluid from patients with Alzheimer type and Binswanger type dementias before and after administration of citalopram, a synthetic serotonin uptake inhibitor.J Neural Transm Park Dis Dement Sect. 1995;9(2-3):121-31. doi: 10.1007/BF02259654. J Neural Transm Park Dis Dement Sect. 1995. PMID: 8526997 Clinical Trial.
-
Concentrations of serotonin and its related substances in the cerebrospinal fluid of parkinsonian patients and their relations to the severity of symptoms.Neurosci Lett. 1993 Feb 5;150(1):71-4. doi: 10.1016/0304-3940(93)90111-w. Neurosci Lett. 1993. PMID: 7682308
-
Serotoninergic system in dementia of the Alzheimer type. Abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid.Arch Neurol. 1985 Dec;42(12):1158-61. doi: 10.1001/archneur.1985.04060110040013. Arch Neurol. 1985. PMID: 2415092
-
Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer's dementia.J Neural Transm Suppl. 1990;30:33-43. doi: 10.1007/978-3-7091-3345-3_4. J Neural Transm Suppl. 1990. PMID: 2202785 Review.
-
Mechanism of acute tryptophan depletion: is it only serotonin?Mol Psychiatry. 2011 Jul;16(7):695-713. doi: 10.1038/mp.2011.9. Epub 2011 Feb 22. Mol Psychiatry. 2011. PMID: 21339754 Review.
Cited by
-
Cerebrospinal fluid acetylcholine and choline in vascular dementia of Binswanger and multiple small infarct types as compared with Alzheimer-type dementia.J Neural Transm (Vienna). 1996;103(10):1211-20. doi: 10.1007/BF01271206. J Neural Transm (Vienna). 1996. PMID: 9013408
-
Melatonin levels in the Alzheimer's disease continuum: a systematic review.Alzheimers Res Ther. 2021 Feb 23;13(1):52. doi: 10.1186/s13195-021-00788-6. Alzheimers Res Ther. 2021. PMID: 33622399 Free PMC article.
-
From Chemotherapy-Induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT3 Receptor Antagonists.Mol Neurobiol. 2015 Dec;52(3):1670-1679. doi: 10.1007/s12035-014-8957-5. Epub 2014 Nov 7. Mol Neurobiol. 2015. PMID: 25377794 Review.
-
An Investigation into the Relationship of Circulating Gut Microbiome Molecules and Inflammatory Markers with the Risk of Incident Dementia in Later Life.Mol Neurobiol. 2024 Dec;61(12):9776-9793. doi: 10.1007/s12035-023-03513-6. Epub 2023 Aug 22. Mol Neurobiol. 2024. PMID: 37605096 Free PMC article.
-
Circadian rhythm sleep disorders: pathophysiology and potential approaches to management.CNS Drugs. 2001;15(4):311-28. doi: 10.2165/00023210-200115040-00005. CNS Drugs. 2001. PMID: 11463135 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
