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. 1992 Jul 6;141(1):9-12.
doi: 10.1016/0304-3940(92)90322-x.

Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia

H Tohgi  1 , T Abe, S Takahashi, M Kimura, J Takahashi, T Kikuchi
Affiliations

Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia

H Tohgi et al. Neurosci Lett. .

Abstract

We studied concentrations of free and total serotonin (5-hydroxytryptamine, 5-HT) and its related substances in the cerebrospinal fluid from patients with Alzheimer type dementia (ATD) compared with controls. In ATD patients, concentrations of total 5-HT, tryptophan, 5-hydroxytryptophan (5-HTP), melatonin, kynurenine, and 3-hydroxykynurenine decreased significantly. The rate of concentration of tryptophan metabolites to that of tryptophan was significantly reduced for total 5-HT and 3-hydroxykynurenine only. The 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio was significantly larger in ATD patients than in controls. The greater reduction in the 3-hydroxykynurenine concentration (81% vs. controls) than in the total 5-HT concentration (51% vs. controls) suggests that the metabolism of tryptophan to 5-HT and 3-hydroxykynurenine is in favor of 5-HT.

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