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Review
. 2004 Apr;20(4):362-3.
doi: 10.1016/s1074-7613(04)00086-x.

Proteasomes get by with lots of help from their friends

Jonathan W Yewdell  1 , Michael F Princiotta
Affiliations
Free article
Review

Proteasomes get by with lots of help from their friends

Jonathan W Yewdell et al. Immunity. 2004 Apr.
Free article

Abstract

Proteasomes can't do it all. It was previously known that aminopeptidases frequently degrade proteasome-generated peptides. Now it appears that another protease, tripeptidyl peptidase II (TPP II), plays a critical role in cleaving proteasomal produced peptides into shorter peptides that can then be degraded by aminopeptidases.

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