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. 2004 May;75(5):785-7.
doi: 10.1136/jnnp.2003.020446.

Imidazoline I(2) receptor density increases with the malignancy of human gliomas

L F Callado  1 , J I Martín-Gómez, J Ruiz, J M Garibi, J J Meana
Affiliations

Imidazoline I(2) receptor density increases with the malignancy of human gliomas

L F Callado et al. J Neurol Neurosurg Psychiatry. 2004 May.

Abstract

Background: Current glioma grading schemes are limited by subjective histological criteria. Imidazoline I(2) receptors are principally expressed on glial cells.

Objective: To investigate the feasibility of using the measurement of imidazoline I(2) receptor expression to differentiate glial tumours from other types of brain tumours and for grading the different gliomas.

Methods: The specific binding of [(3)H]idazoxan to imidazoline I(2) receptors was measured in homogenates from human gliomas of different grades.

Results: The density of imidazoline I(2) receptors was significantly greater in the three types of malignant glial tumours than in postmortem control brain or non-glial tumours. The increase in density correlated with the malignancy grade of the gliomas. No significant differences in affinity values were observed.

Conclusion: These results suggest that the density of imidazoline I(2) receptors may be a useful radioligand parameter for the differentiation of glial tumours from other types of brain tumours and for grading the different gliomas.

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