doi: 10.1126/science.257.5073.1134.
Transactivation by AP-1 is a molecular target of T cell clonal anergy
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- PMID: 1509265
- DOI: 10.1126/science.257.5073.1134
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Transactivation by AP-1 is a molecular target of T cell clonal anergy
Science.
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Abstract
Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.
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