Heterogeneous nuclear ribonucleoprotein E2 binds to tau exon 10 and moderately activates its splicing
- PMID: 15094196
- DOI: 10.1016/j.gene.2004.02.005
Heterogeneous nuclear ribonucleoprotein E2 binds to tau exon 10 and moderately activates its splicing
Abstract
Tau is a microtubule-associated protein whose transcript undergoes complex-regulated splicing in the mammalian nervous system. Exon 10 of the gene is an alternatively spliced cassette, which is adult-specific and codes for a microtubule-binding domain. Mutations that affect splicing of exon 10 have been shown to cause frontotemporal dementia with parkinsonism (FTDP). Using tau exon 10 as a bait in a yeast three-hybrid screen, we discovered that it interacts with hnRNPE2. Cotransfection assays show that hnRNPE2 isoforms moderately activate the splicing of exon 10.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources