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Comment
. 2004 Apr;2(4):E125.
doi: 10.1371/journal.pbio.0020125. Epub 2004 Apr 13.

Yeast prions: protein aggregation is not enough

Michael Y Sherman  1
Affiliations
Comment

Yeast prions: protein aggregation is not enough

Michael Y Sherman. PLoS Biol. 2004 Apr.

Abstract

Although many proteins -- both damaged and normal -- have a tendency to aggregate, only some are capable of dividing and propagating. What does it take to turn a protein aggregate into an infectious prion?

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Figures

Figure 1
Figure 1. Aggregation, Division, and Transfer of Prions in Yeast
Figure 2
Figure 2. Distinct Domains of Sup35 Are Responsible for Aggregation and Division of Aggregates
See this image and copyright information in PMC

Comment on

  • Dissection and design of yeast prions.
    Osherovich LZ, Cox BS, Tuite MF, Weissman JS. Osherovich LZ, et al. PLoS Biol. 2004 Apr;2(4):E86. doi: 10.1371/journal.pbio.0020086. Epub 2004 Mar 23. PLoS Biol. 2004. PMID: 15045026 Free PMC article.

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