doi: 10.1021/ja049569g.
Total synthesis of (+/-)-perophoramidine
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- PMID: 15099080
- DOI: 10.1021/ja049569g
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Total synthesis of (+/-)-perophoramidine
J Am Chem Soc.
.
Abstract
The first total synthesis of racemic perophoramidine is described. The key step features the highly stereoselective introduction of the vicinial quaternary centers via base-promoted carbon-carbon bond formation between a 3-alkylindole and a 3-bromo-3-alkylindolin-2-one. This transformation presumably proceeds through a conjugate addition or Diels-Alder cycloaddition of the 3-alkylindole with a 3-alkylindol-2-one intermediate.
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