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. 2004 Apr 23;14(2):148-50.
doi: 10.1016/s1097-2765(04)00207-2.

Tension precedes commitment-even for a stem cell

Jeffrey Settleman  1
Affiliations
Free article

Tension precedes commitment-even for a stem cell

Jeffrey Settleman. Mol Cell. .
Free article

Abstract

The differentiation potential of stem cells is influenced by cell density. An article in the April issue of Developmental Cell demonstrates that lineage commitment by mesenchymal stem cells is regulated by shape-induced changes in Rho GTPase activity and cytoskeletal tension.

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