Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jan;35(1-2):130-4.
doi: 10.1007/BF01990962.

Calcium channel blockers prevent stress-induced ulcers in rats

B C Yegen  1 , I Alican, A S Yalçin, S Oktay
Affiliations

Calcium channel blockers prevent stress-induced ulcers in rats

B C Yegen et al. Agents Actions. 1992 Jan.

Abstract

Gastric mucosal damage induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Am J Physiol. 1987 Jan;252(1 Pt 1):G1-7 - PubMed
    1. Res Commun Chem Pathol Pharmacol. 1984 Jul;45(1):153-6 - PubMed
    1. Br J Pharmacol. 1989 Aug;97(4):1085-92 - PubMed
    1. Scand J Gastroenterol. 1982 Jun;17(4):533-8 - PubMed
    1. Dig Dis Sci. 1988 Jul;33(7):865-71 - PubMed