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. 1992 Jan;35(1-2):130-4.
doi: 10.1007/BF01990962.

Calcium channel blockers prevent stress-induced ulcers in rats

B C Yegen  1 , I Alican, A S Yalçin, S Oktay
Affiliations

Calcium channel blockers prevent stress-induced ulcers in rats

B C Yegen et al. Agents Actions. 1992 Jan.

Abstract

Gastric mucosal damage induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.

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