Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 May;97(5):293-6.
doi: 10.1093/qjmed/hch050.

Dehydration and venous thromboembolism after acute stroke

J Kelly  1 , B J Hunt, R R Lewis, R Swaminathan, A Moody, P T Seed, A Rudd
Affiliations

Dehydration and venous thromboembolism after acute stroke

J Kelly et al. QJM. 2004 May.

Abstract

Background: Although it is widely assumed that dehydration predisposes to venous thromboembolism (VTE), there are no clinical studies to support this.

Aim: To evaluate the relationship between biochemical indices of dehydration and VTE after acute ischaemic stroke (AIS).

Design: Prospective observational study.

Methods: Unselected AIS patients (n = 102) receiving standard thromboprophylaxis with aspirin and graded compression stockings, underwent serial measurements of serum urea, creatinine and osmolality, and were screened for VTE using magnetic resonance direct thrombus imaging.

Results: Serum osmolality of >297 mOsm/kg, urea >7.5 mmol/l and urea:creatinine ratio (mmol:mmol) >80 a few days post-AIS were associated with odds ratios for VTE of, respectively, 4.7, 2.8 and 3.4 (p = 0.02, 0.05, 0.02) on multivariable analysis.

Discussion: Dehydration after AIS is strongly independently associated with VTE, reinforcing the importance of maintaining adequate hydration in these patients.

PubMed Disclaimer