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. 2004 May;72(5):3038-41.
doi: 10.1128/IAI.72.5.3038-3041.2004.

The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice

Riccardo Manganelli  1 , Lanfranco Fattorini, Dejiang Tan, Elisabetta Iona, Graziella Orefici, Giuseppe Altavilla, Paola Cusatelli, Issar Smith
Affiliations

The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice

Riccardo Manganelli et al. Infect Immun. 2004 May.

Abstract

The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.

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Figures

FIG. 1.
FIG. 1.
Time-to-death analysis in SCID mice after intravenous infection with H37Rv (filled circles) and with the sigE mutant strain (empty circles).
FIG. 2.
FIG. 2.
Growth rate of H37Rv (filled circles), the sigE mutant strain (empty circles), and the complemented mutant (filled squares) in livers (A), spleens (B), and lungs (C) of BALB/c mice.
FIG. 3.
FIG. 3.
Histopathological analysis of BALB/c mouse lungs after 21 days of infection with M. tuberculosis H37Rv (A and C) or the sigE mutant strain (B and D). Stains: Ziehl-Neelsen stain (A and B); hematoxylin stain (C and D).
See this image and copyright information in PMC

References

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