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. 1992 May;36(5):1151-4.
doi: 10.1128/AAC.36.5.1151.

Genetics and regulation of outer membrane protein expression by quinolone resistance loci nfxB, nfxC, and cfxB

D C Hooper  1 , J S Wolfson, M A Bozza, E Y Ng
Affiliations

Genetics and regulation of outer membrane protein expression by quinolone resistance loci nfxB, nfxC, and cfxB

D C Hooper et al. Antimicrob Agents Chemother. 1992 May.

Abstract

Quinolone resistance mutations (cfxB1, marA1, and soxQ1) that reduce porin outer membrane protein OmpF map near 34 min on the Escherichia coli chromosome. Another such mutation, nfxC1, was found in strain KF131 (nfxB, 19 min). nfxC1 and cfxB1 mutants (selected with quinolones) differed slightly but reproducibly from marA1 (selected with tetracycline) and soxQ1 (selected with menadione) mutants in quinolone resistance and linkage to zdd2208::Tn10kan (33.7 min). For nfxB nfxC1 and cfxB1 mutants, as previously shown for marA mutants, resistance and reduced OmpF required the micF locus encoding an antisense RNA complementary to ompF mRNA and were associated with increased micF expression.

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References

    1. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4772-6 - PubMed
    1. J Mol Biol. 1981 Feb 15;146(1):23-43 - PubMed
    1. J Bacteriol. 1991 Sep;173(17):5532-8 - PubMed
    1. J Bacteriol. 1987 Oct;169(10):4722-30 - PubMed
    1. Antimicrob Agents Chemother. 1989 Mar;33(3):283-90 - PubMed

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