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Review
. 2004 Jun;24(6):1023-30.
doi: 10.1161/01.ATV.0000128897.54893.26. Epub 2004 Apr 22.

Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway

Patrick Vallance  1 , James Leiper
Affiliations
Review

Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway

Patrick Vallance et al. Arterioscler Thromb Vasc Biol. 2004 Jun.

Abstract

An increasing number of reports indicate that endogenously produced inhibitors of nitric oxide synthase, particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for cardiovascular physiology and pathophysiology.

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