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. 2004;2004(2):CD003538.
doi: 10.1002/14651858.CD003538.pub2.

Selenium supplementation for asthma

M F Allam  1 , R A Lucane
Affiliations

Selenium supplementation for asthma

M F Allam et al. Cochrane Database Syst Rev. 2004.

Abstract

Background: Selenium deficiency may be important in chronic asthma. Observational studies have demonstrated that patients with chronic asthma may have lower levels of selenium than their control. Nevertheless, selenium supplementation has not been recommended with drug therapy for asthma. This review systematically examines RCTs that evaluated the role of selenium supplementation in chronic asthma.

Objectives: Recognition that chronic asthma can be associated with selenium deficiency has led to the investigation of the role of selenium supplementation in reducing the symptoms and impact of chronic asthma. The objective of this review was to assess the efficacy of selenium supplementation as an adjunct to medication for the treatment of chronic asthma.

Search strategy: We searched the Cochrane Airways Group trials register, MEDLINE/PUB MED, and EMBASE. Searches were current as of August 2003.

Selection criteria: Randomised trials comparing patients with chronic asthma receiving selenium supplementation in conjunction with asthma medication, with patients taking asthma medication only.

Data collection and analysis: Two reviewers applied the study inclusion criteria

Main results: One trial with a total of 24 patients suffering from chronic asthma was included. The study reported significant clinical improvement in the selenium-supplemented group, as compared with the placebo group, in terms of a 'clinical evaluation'. However, this improvement could not be validated by significant changes in separate objective parameters of lung function and airway hyper-responsiveness.

Reviewers' conclusions: There is some indication that selenium supplementation may be a useful adjunct to medication for patients with chronic asthma. This conclusion is limited because of insufficient studies and lack of improvement in the clinical parameters of lung function.

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Conflict of interest statement

None known.

Figures

1.1
1.1. Analysis
Comparison 1 Selenium plus usual care versus placebo plus usual care, Outcome 1 Improvement (based on assembled clinical evaluation).
See this image and copyright information in PMC

Update of

References

References to studies included in this review

Hasselmark 1993 {published data only}
    1. Hasselmark L, Malmgren R, Zetterstrom O, Unge G. [Selenium supplementation in intrinsic asthma]. Allergy 1993;48(1):30‐6. - PubMed

References to studies excluded from this review

Fenech 1998 {published data only}
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Gazdik 2002 {published data only}
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Hasselmark 1990 {published data only}
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Additional references

BTS 2003
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