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. 1992 Aug 4;44(3):596-600.
doi: 10.1016/0006-2952(92)90456-s.

Induction of rat hepatic and intestinal glutathione S-transferases by dietary butylated hydroxyanisole

W A Nijhoff  1 , W H Peters
Affiliations

Induction of rat hepatic and intestinal glutathione S-transferases by dietary butylated hydroxyanisole

W A Nijhoff et al. Biochem Pharmacol. .

Abstract

To obtain insight into the protection mechanism of butylated hydroxyanisole (BHA), a widely used food preservative with anticarcinogenic properties, we investigated the effects of dietary BHA on rat hepatic and intestinal glutathione S-transferase (GST) enzyme activity, and GST isozyme levels. In the proximal small intestine and liver, BHA supplementation significantly increased GST enzyme activity as compared with controls (2.3- and 1.7-fold, respectively, P less than 0.05). GST class alpha and mu contents were significantly higher only in the small intestine (1.6-2.1-fold and 1.3-1.5-fold, respectively, P less than 0.05), whereas GST class pi was significantly induced in liver (4.6-fold, P less than 0.05).

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