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Case Reports
. 2004 Mar;10(3):497-500.
doi: 10.3201/eid1003.030513.

Human metapneumovirus-associated atypical pneumonia and SARS

Paul K S Chan  1 , Ka-Fai To, Alan Wu, Gary M K Tse, Kui-Fat Chan, Siu-Fai Lui, Joseph J Y Sung, John S Tam, Brian Tomlinson
Affiliations
Case Reports

Human metapneumovirus-associated atypical pneumonia and SARS

Paul K S Chan et al. Emerg Infect Dis. 2004 Mar.

Abstract

Acute pneumonia developed in a previously healthy man during the outbreak of severe acute respiratory syndrome (SARS) in southern China in March 2003. Antibiotic treatment was ineffective, and he died 8 days after illness onset. Human metapneumovirus was isolated from lung tissue. No other pathogen was found. Other etiologic agents should thus be sought in apparent SARS cases when coronavirus infection cannot be confirmed.

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Figures

Figure
Figure
Pathologic findings of lung tissue sections. A: Pulmonary congestion and edema (H&E stain, original magnification x100). B: A mild degree of interstitial lymphocytic infiltration. Intra-alveolar organizing exudative lesion was occasionally found. Detached atypical pneumocytes indicated by arrow (H&E stain, original magnification x200). C: Atypical multinucleated pneumocytes were occasionally identified. Definite viral inclusion was not apparent (H&E stain, original magnification x400). D: Fibrin thrombi were frequently noted in small pulmonary arteries and arterioles (H&E stain, original magnification x200).
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