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. 2004 May 1;10(9):1379-81.
doi: 10.3748/wjg.v10.i9.1379.

Evaluation of effect of hybrid bioartificial liver using end-stage liver disease model

Qing Liu  1 , Zhong-Ping Duan, Chun Huang, Chun-Hui Zhao
Affiliations

Evaluation of effect of hybrid bioartificial liver using end-stage liver disease model

Qing Liu et al. World J Gastroenterol. .

Abstract

Aim: To study the role of hybrid bioartificial liver (HBL) in clearing proinflammatory cytokines and endotoxin in patients with acute and sub-acute liver failure and the effects of HBL on systemic inflammatory syndrome (SIRS) and multiple organ dysfunction syndrome (MODS).

Methods: Five cases with severe liver failure (3 acute and 2 subacute) were treated with HBL. The clinical signs and symptoms, total bilirubin (TBIL), serum ammonia, endotoxin TNF-alpha, IL-6 and prothrombin activity (PTA),cholinesterase (CHE) were recorded before, during and after treatment. The end-stage liver disease (MELD) was used for the study.

Results: Two patients were bridged for spontaneous recovery and 1 patient was bridged for OLT successfully. Another 2 patients died on d 8 and d 21. The spontaneous recovery rate was 30.0%. PTA and CHE in all patients were significantly increased (P<0.01), while the serum TBIL, endotoxin, TNF-alpha, IL-6 were decreased. MELD score (mean 43.6) predicted 100% deaths within 3 mo before treatment with HBL. After treatment with HBL, four out of 5 patients had decreased MELD scores (mean 36.6). The MELD score predicted 66% mortalities.

Conclusion: The proinflammatory cytokines (TNFalpha, IL-6 and endotoxin)can be significantly removed by hybrid bioartificial liver and HBL appears to be effective in blocking SIRS and MODS in patients with acute and sub-acute liver failure. MELD is a reliable measure for predicting short-term mortality risk in patients with end-stage liver disease. The prognostic result also corresponds to clinical outcome.

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Figures

Figure 1
Figure 1
Change of cytokines and LPS in different points.
See this image and copyright information in PMC

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References

    1. Fifth conference of national contagious disease and parasitic dis-ease Guideline: prevention and treatment of virus hepatitis (draft) Zhonghua Neike Zazhi. 1995;34:788–791.
    1. Qiu HB, Zhou SX, Yang Y. Multiple organ dysfunction syndrom predictors of mortality and clinical therapetic strategies. Linchuang Jjijiuy Yixue. 2001;10:13–16.
    1. Fry DE, Pearlstein L, Fulton RL, Polk HC. Multiple system organ failure. The role of uncontrolled infection. Arch Surg. 1980;115:136–140. - PubMed
    1. Xue YL, Zhao SF, Zhang ZY, Wang YF, Li XJ, Huang XQ, Luo Y, Huang YC, Liu CG. Effects of a bioartificial liver support system on acetaminophen induced acute liver failure canines. World J Gastroenterol. 1999;5:308–311. - PMC - PubMed
    1. Zimmerman JE, Knaus WA, Sun X, Wagner DP. Severity stratification and outcome prediction for multisystem organ failure and dysfunction. World J Surg. 1996;20:401–405. - PubMed

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