Review
[Protective effect of carbon monoxide for organ injury]
[Article in
Japanese]
Affiliations
- PMID: 15112495
Item in Clipboard
Review
[Protective effect of carbon monoxide for organ injury]
[Article in
Japanese]
Nihon Geka Gakkai Zasshi.
2004 Apr.
Abstract
Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.
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