doi: 10.1136/jnnp.41.9.809.
Platelet monoamine oxidase activity in Huntington's chorea
- PMID: 151126
- PMCID: PMC493159
- DOI: 10.1136/jnnp.41.9.809
Item in Clipboard
Platelet monoamine oxidase activity in Huntington's chorea
J Neurol Neurosurg Psychiatry.
1978 Sep.
Abstract
The possibility that genetically determined abnormalities in the monoamine oxidase of certain central nervous system aminergic neurones may play a part in the pathology of Huntington's chorea was investigated using human platelet monoamine oxidase. Significantly elevated monoamine oxidase activity was found in male patients compared to control subjects suggesting this may be a screening test for this disorder. Low monoamine oxidase activity was associated with a better clinical response to drugs.
Similar articles
-
Platelet monoamine oxidase activity in patients with Huntington's disease.Clin Exp Pharmacol Physiol. 1987 Jun;14(6):547-50. doi: 10.1111/j.1440-1681.1987.tb01511.x. Clin Exp Pharmacol Physiol. 1987. PMID: 2960476
-
Platelet monoamine oxidase activity in subjects tested for Huntington's disease gene mutation.J Neural Transm (Vienna). 2004 Apr;111(4):475-83. doi: 10.1007/s00702-003-0103-x. Epub 2004 Feb 4. J Neural Transm (Vienna). 2004. PMID: 15057517
-
Combined therapy with tetrabenazine and pimozide in Huntington's chorea: pilot study.N Z Med J. 1976 Feb 25;83(558):114-6. N Z Med J. 1976. PMID: 131917
-
Human platelet monoamine oxidase activity in health and disease: a review.J Clin Pathol. 1981 Mar;34(3):292-302. doi: 10.1136/jcp.34.3.292. J Clin Pathol. 1981. PMID: 6453137 Free PMC article. Review.
-
Tetrabenazine (Xenazine) for Huntington's chorea.Med Lett Drugs Ther. 2009 Jan 26;51(1304):7-8. Med Lett Drugs Ther. 2009. PMID: 19172140 Review. No abstract available.
Cited by
-
Abnormal platelet aggregation response in Huntington's disease.Arch Psychiatr Nervenkr (1970). 1982;232(3):191-200. doi: 10.1007/BF02141780. Arch Psychiatr Nervenkr (1970). 1982. PMID: 6218794
-
Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.Mol Neurobiol. 2015 Dec;52(3):1850-1861. doi: 10.1007/s12035-014-8974-4. Epub 2014 Nov 15. Mol Neurobiol. 2015. PMID: 25398695 Free PMC article.
-
Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence.Int Rev Neurobiol. 2011;100:13-42. doi: 10.1016/B978-0-12-386467-3.00002-9. Int Rev Neurobiol. 2011. PMID: 21971001 Free PMC article. Review.
-
The current state of research with peripheral tissues in Huntington disease.Hum Genet. 1984;66(2-3):115-31. doi: 10.1007/BF00286586. Hum Genet. 1984. PMID: 6325322 Review.
-
Tau levels in platelets isolated from Huntington's disease patients serve as a biomarker of disease severity.J Neurol. 2025 Mar 6;272(3):254. doi: 10.1007/s00415-025-12966-9. J Neurol. 2025. PMID: 40047995 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
