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. 2004;54(3):139-42.
doi: 10.1055/s-0031-1296950.

Determination of gabapentin-lactam in serum of patients under gabapentin therapy

Rainer Knörle  1 , Thomas J Feuerstein, Andreas Schulze-Bonhage
Affiliations

Determination of gabapentin-lactam in serum of patients under gabapentin therapy

Rainer Knörle et al. Arzneimittelforschung. 2004.

Abstract

Gabapentin (1-(aminomethyl)cyclohexane acetic acid, CAS 601 42-96-3, GBP, Neurontin) and its derivative gabapentin-lactam (8-aza-spiro[5,4]decan-9-one, GBP-L) were determined by HPLC in the serum of patients with focal epilepsy treated with GBP. In patients in whom serum was acquired within 3 h after oral intake, GBP-L could be detected at concentrations up to 8.2 micromol/l. As GBP-L has been previously shown to exert neuroprotective effects in a similar concentration range, this finding suggests that clinically relevant effects of GBP-L may occur in patients treated with GBP. The possible neuroprotective efficacy of GBP-L should be the subject of further preclinical and clinical investigations.

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