Aureolic acids: similar antibiotics with different biosynthetic gene clusters
- PMID: 15112986
- DOI: 10.1016/j.chembiol.2004.01.006
Aureolic acids: similar antibiotics with different biosynthetic gene clusters
Abstract
In this issue of Chemistry & Biology, Méndez and colleagues describe the sequence and organization of the chromomycin gene cluster. Unexpectedly, the arrangement is starkly different from the mithramycin biosynthetic cluster, despite similarity in the individual genes and the near identical structures of the two antibiotic aureolic acids.
Comment on
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Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.Chem Biol. 2004 Jan;11(1):21-32. doi: 10.1016/j.chembiol.2003.12.011. Chem Biol. 2004. PMID: 15112992
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