Comment
doi: 10.1016/j.chembiol.2004.01.006.
Aureolic acids: similar antibiotics with different biosynthetic gene clusters
Affiliations
- PMID: 15112986
- DOI: 10.1016/j.chembiol.2004.01.006
Item in Clipboard
Comment
Aureolic acids: similar antibiotics with different biosynthetic gene clusters
Chem Biol.
2004 Jan.
Abstract
In this issue of Chemistry & Biology, Méndez and colleagues describe the sequence and organization of the chromomycin gene cluster. Unexpectedly, the arrangement is starkly different from the mithramycin biosynthetic cluster, despite similarity in the individual genes and the near identical structures of the two antibiotic aureolic acids.
Comment on
-
Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.Chem Biol. 2004 Jan;11(1):21-32. doi: 10.1016/j.chembiol.2003.12.011. Chem Biol. 2004. PMID: 15112992
Similar articles
-
Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.Chem Biol. 2004 Jan;11(1):21-32. doi: 10.1016/j.chembiol.2003.12.011. Chem Biol. 2004. PMID: 15112992
-
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives.Appl Microbiol Biotechnol. 2006 Nov;73(1):1-14. doi: 10.1007/s00253-006-0511-6. Epub 2006 Sep 30. Appl Microbiol Biotechnol. 2006. PMID: 17013601 Review.
-
Association of antitumor antibiotics, mithramycin and chromomycin, with Zn(II).J Inorg Biochem. 2007 Jan;101(1):127-37. doi: 10.1016/j.jinorgbio.2006.08.018. Epub 2006 Sep 20. J Inorg Biochem. 2007. PMID: 17070920
-
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.FEMS Microbiol Lett. 2000 May 1;186(1):61-5. doi: 10.1111/j.1574-6968.2000.tb09082.x. FEMS Microbiol Lett. 2000. PMID: 10779713
-
The biosynthetic gene clusters of aminocoumarin antibiotics.Planta Med. 2006 Oct;72(12):1093-9. doi: 10.1055/s-2006-946699. Epub 2006 Jul 25. Planta Med. 2006. PMID: 16868863 Review.
Cited by
-
Molecular insight into substrate recognition and catalysis of Baeyer-Villiger monooxygenase MtmOIV, the key frame-modifying enzyme in the biosynthesis of anticancer agent mithramycin.ACS Chem Biol. 2013 Nov 15;8(11):2466-77. doi: 10.1021/cb400399b. Epub 2013 Sep 13. ACS Chem Biol. 2013. PMID: 23992662 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
