Unraveling the pathway of lipoic acid biosynthesis
- PMID: 15112987
- DOI: 10.1016/j.chembiol.2004.01.002
Unraveling the pathway of lipoic acid biosynthesis
Abstract
Lipoic acid is almost universally required for aerobic metabolism. However, the mechanism for its synthesis and incorporation into proteins has remained elusive. A groundbreaking study published in the December issue of Chemistry & Biology uncovers critical features of the lipoic acid biosynthetic pathway.
Comment on
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Assembly of the covalent linkage between lipoic acid and its cognate enzymes.Chem Biol. 2003 Dec;10(12):1293-302. doi: 10.1016/j.chembiol.2003.11.016. Chem Biol. 2003. PMID: 14700636
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