Review
doi: 10.1016/j.chembiol.2004.01.008.
Profound insights into squalene cyclization
Affiliations
- PMID: 15112988
- DOI: 10.1016/j.chembiol.2004.01.008
Item in Clipboard
Review
Profound insights into squalene cyclization
Chem Biol.
2004 Jan.
Free article
Abstract
In this issue of Chemistry & Biology, our understanding of the formation of pentacyclic hopene from the linear squalene is enhanced by an X-ray structure of a complex between squalene-hopene cyclase and the substrate analog 2-azasqualene.
Comment on
-
Conversion of squalene to the pentacarbocyclic hopene.Chem Biol. 2004 Jan;11(1):121-6. doi: 10.1016/j.chembiol.2003.12.013. Chem Biol. 2004. PMID: 15113001
Similar articles
-
Conversion of squalene to the pentacarbocyclic hopene.Chem Biol. 2004 Jan;11(1):121-6. doi: 10.1016/j.chembiol.2003.12.013. Chem Biol. 2004. PMID: 15113001
-
Concerted nature of AB ring formation in the enzymatic cyclization of squalene to hopenes.Org Lett. 2004 May 27;6(11):1717-20. doi: 10.1021/ol0496125. Org Lett. 2004. PMID: 15151397
-
Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that of the eukaryotic-type cyclase specific to (3S)-2,3-oxidosqualene.Angew Chem Int Ed Engl. 2004 Dec 10;43(48):6700-3. doi: 10.1002/anie.200461523. Angew Chem Int Ed Engl. 2004. PMID: 15593147 No abstract available.
-
Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships.Chem Rec. 2008;8(5):302-25. doi: 10.1002/tcr.20157. Chem Rec. 2008. PMID: 18956480 Review.
-
Enzymatic synthesis of cyclic triterpenes.Nat Prod Rep. 2007 Dec;24(6):1311-31. doi: 10.1039/b616857b. Epub 2007 Aug 7. Nat Prod Rep. 2007. PMID: 18033581 Review.
Cited by
-
Squalene-hopene cyclases.Appl Environ Microbiol. 2011 Jun;77(12):3905-15. doi: 10.1128/AEM.00300-11. Epub 2011 Apr 29. Appl Environ Microbiol. 2011. PMID: 21531832 Free PMC article. Review.
-
Modeling linear and cyclic PKS intermediates through atom replacement.J Am Chem Soc. 2014 Dec 3;136(48):16792-9. doi: 10.1021/ja5064857. Epub 2014 Nov 19. J Am Chem Soc. 2014. PMID: 25406716 Free PMC article.
-
A Major Locus on Wheat Chromosome 7B Associated With Late-Maturity α-Amylase Encodes a Putative ent-Copalyl Diphosphate Synthase.Front Plant Sci. 2021 Feb 26;12:637685. doi: 10.3389/fpls.2021.637685. eCollection 2021. Front Plant Sci. 2021. PMID: 33719315 Free PMC article.
-
Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase.PLoS One. 2011;6(7):e22134. doi: 10.1371/journal.pone.0022134. Epub 2011 Jul 21. PLoS One. 2011. PMID: 21811565 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
