doi: 10.1016/0006-8993(92)91226-5.
Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by androgenic-anabolic steroids
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- PMID: 1511313
- DOI: 10.1016/0006-8993(92)91226-5
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Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by androgenic-anabolic steroids
Brain Res.
.
Abstract
To determine whether androgenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir), were examined in hippocampi of adrenalectomized male rats. Treatment with AAS for 1 week increased nuclear GRir in pyramidal cells of CA1, and granule cells of the dentate gyrus. These findings suggest a role for GR in the mediation of some of the CNS effects of androgenic-anabolic steroids.
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